The evolvement of proteolysis as a centrally important regulatory mechanism is a remarkable example for the development of a novel biological concept and the accompanying battles to change paradigms.
Aaron Ciechanover
We pop into existence and we know that we die and we know that we lose everyone that we love and we know we even lose our own bodies. And what a paradigm. What a mystery.
Adrianne Lenker
Given the rapid rate of change, the old paradigm of one-off education followed by a career will no longer work: life-long learning is a must, and it is up to governments and employers to invest in training and for employees to commit to constantly update their skill set.
Alain Dehaze
I am a little suspicious of industry paradigms. I feel like so many movies and TV shows feel so familiar because of over-reliance on these paradigms.
Alan Ball
People don't use Evite or Facebook events for their weddings. But they do use Paperless Post. It's the sign of a paradigm because it is the most momentous occasion in most people's lives. It represents the most formal type of offline communication.
Alexa Hirschfeld
The progressive integration of new technologies in our economy amounts to a paradigm shift with a profound impact on the context and content of work.
Alexander De Croo
Almost all the knowledge required to produce more food than eroding soil is available today - we just need to use that knowledge within a holistic paradigm - managing agriculture holistically, forming the policies that undergird it holistically.
Allan Savory
When I speak of diversity, I don't mean replacement of white comics. I don't mean acceptance by white comics. We comics who weren't born into the white guy paradigm of 'funny' don't need a handout. We don't need a PC push. We don't need 'a look.'
Amanda Seales
Every time you see a new paradigm emerge, it's always new vendors that lead it. I can't think of one case where an incumbent led a paradigm shift.
Aneel Bhusri
President Karzai was an accidental president. There was no paradigm for the conditions he faced, because no one could have imagined 9/11. He had to improvise under very difficult conditions to hold this country together.
Ashraf Ghani
As an athlete, you really see a lot of the Instagram paradigm. Where it's just like, 'Me! Me! Me!' When you realize you can 'Give, Give, Give,' it's very interesting, and it's good.
Ashton Eaton
I wanted to make a record that worked against the hypnagogic paradigm, for sure.
Autre Ne Veut
I intend to be making films until I'm an old lady. So, if God willing I get there, I need to create a paradigm for myself where I can make it regardless of whether or not they still like what I'm making.
Ava DuVernay
I see the American experience as being defined by the immigrant paradigm of rupture and renewal: rupture with the old world, the old ways, and renewal of the self in a bright but difficult New World.
Ayad Akhtar
I think you choose how you walk through this life. I think if you choose to participate in a paradigm that is looks-based, if you're an actor, then it can be empowering in some ways, and it can be really limiting in some ways in terms of time and longevity.
Bellamy Young
The bad thing about young people starting a company is that sometimes they do it for the wrong reasons or because they have the wrong skill set, but the good thing is that they don't have any of the old paradigms baked into them, so they have a lot of the bright new ideas that are harder to come by as you get older.
Ben Horowitz
Our nation's commitment is to provide a quality education to every child to serve the public common good. Accordingly, we must shift the paradigm to think of education funding as investments made in individual children, not in institutions or buildings.
Betsy DeVos
We started Ashoka here in India with a simple idea: that you needed social entrepreneurs to deal with problems that don't fit the business paradigm.
Bill Drayton
I find languages that support just one programming paradigm constraining.
Bjarne Stroustrup
The strange thing was, when I was starting on YouTube, even the paradigm of YouTube and Internet sensation - or whatever - that didn't really exist. So I didn't even know that that was a thing.
Bo Burnham
God's Spirit moves through us and the world at a pace that can never be constricted by any one religious paradigm.
God's Spirit moves through us and the world at a pace that can never be constricted by any one religious paradigm. I love that.
The strategic marketing paradigm of Open Source is a massively-parallel drunkard's walk filtered by a Darwinistic process.
As a scholar who regularly surveys archival material, I think that, a century from now, cultural historians will find David Horowitz's spiritual and political odyssey paradigmatic for our time.
So it's really hard for a horn player to comp. But I'm totally into trying to switch those paradigms around and find a little magic space where that works, and try to mine that.
My typical paradigm is that I do believe in public service. My father's a military man. He really does always speak about the fact that there is actually nothing more valuable that you can do than actually to serve your country. And I buy that.
I love how New York as an idea is less a paradigm of manifest destiny and more a romance for the social orphans of the world. We live here to be among the towers and the crowds.
'Disruption' is, at its core, a really powerful idea. Everyone hijacks the idea to do whatever they want now. It's the same way people hijacked the word 'paradigm' to justify lame things they're trying to sell to mankind.
I've made money by just trying to do world-class science. That's the goal that we're setting at Celera. If we do world-class science and create new medicine paradigms, the money will more than follow at a corporate level and at a personal level.
I think time travel is really tricky. But if there's a logic and a complete and well-thought-through paradigm for it, I think it can be really interesting. Some of my favorite time-travel movies just make me think and, you know, the 'what if' question becomes a big one.
The rules changed for art around 1989. We were all loosed upon the canon to clip and paste and borrow and update. Only thing is, unless you were in New York or in a cultural studies program, that new paradigm probably wasn't going to sink in until the Internet arrived.
With 'Heavy Rain,' we're creating something that changes many traditional game paradigms.
Within psychology and neuroscience, some new and rigorous experimental paradigms for studying consciousness have helped it begin to overcome the stigma that has been attached to the topic for most of this century.
Search as a paradigm will continue to be probably even increasingly important because the information that's out there is only going to grow exponentially - and the only way to sort through all that is by some form of search.
There's like a shift in the paradigm about every 15 years in movies because one would slip through the cracks. I think if they were more inexpensive you would see many more eclectic comedies being made.
The symbolic language of the crucifixion is the death of the old paradigm; resurrection is a leap into a whole new way of thinking.
What happens is consciousness operates in mysterious ways. One of those ways is that the old paradigm suddenly starts to die.
Participating in Miss India was a paradigm shift and I had a blast.
Your paradigm is so intrinsic to your mental process that you are hardly aware of its existence, until you try to communicate with someone with a different paradigm.
The paradigm shift of the ImageNet thinking is that while a lot of people are paying attention to models, let's pay attention to data. Data will redefine how we think about models.
The global healthcare industry is undergoing a paradigm shift, providing significant opportunities for Philips to deliver more integrated solutions across the continuum of care - from prevention, diagnosis, and treatment to monitoring and aftercare.
Tesla is changing the paradigm. We're going to turn the world on its ear and create high demand through design.
Early in my doctoral training at Cornell University, I became immersed in the behavioral decision theory paradigm.
The paradigm for intelligence was logical reasoning, and the idea of what an internal representation would look like was it would be some kind of symbolic structure. That has completely changed with these big neural nets.
We now think of internal representation as great big vectors, and we do not think of logic as the paradigm for how to get things to work. We just think you can have these great big neural nets that learn, and so, instead of programming, you are just going to get them to learn everything.
The paradigm of physics - with its interplay of data, theory and prediction - is the most powerful in science.
Personally, I regard myself as an intellectual 'rebel,' kicking against the 'old colonialism-imperialism paradigm' which has landed Africa in a conundrum.
'The Deuce' takes a look at the remarkable paradigm of capitalism and labor: where money goes and how it's routed; who has power and who doesn't; who is exploited and who's not.
New questions can produce new scientific leaps. They can tiddlywink new flips of insight and understanding. Big ones. Paradigm shifts.
There is a lot of healing going on. Really! More people are vegetarians, more are in the green movement, more of us are tearing down the old paradigms and embracing same-sex marriage, single motherhood, men raising babies.
