Alzheimer's is a disease for which there is no effective treatment whatsoever. To be clear, there is no pharmaceutical agent, no magic pill that a doctor can prescribe that will have any significant effect on the progressive downhill course of this disease.

David Perlmutter

Downhill track sports like luge are technology battles, as exciting as a NASCAR qualifying day.

Alex Berenson

To feel nervous; to feel threatened and vulnerable and alive and engaged in that sense when interacting with someone you're really attracted to? I think that's wonderful. That's usually the best part. In fact, it's almost always downhill from there.

Alex Karpovsky

Our act started at the bottom and went downhill.

Allan Sherman

I think Hitchcock had a thing about hills: think of the house on the hill in 'Psycho.' Then, in 'Vertigo,' Scottie is forever traversing the city, going downhill all the time as he goes deeper and deeper into himself. It's as if Hitchcock is using San Francisco as a psychological map.

Allen Coulter

It's not easy to reach the summit of your career by the age of 24 - and for the years after to be a humiliating scrabble downhill.

Allison Pearson

You have to be aware. Like, I'm not going to do any downhill skiing. It looks like a whole lot of fun, but I'm not going to risk breaking a leg. I want to be dancing the way I'm dancing now for 30 more years.

Bebe Neuwirth

Once you've had success, I think you can go one of two ways. You can either have that success and go downhill, or you can use it to build off of it and continue going upward.

Christian Yelich

Growing up, people will tell you that you have a better chance to become an astronaut than becoming an NBA player. So when you finally get to the NBA, you've beat the odds. So when you put on that jersey, everything else is downhill.

Clyde Drexler

The recreational golfer who gives it careful thought will conclude that the favorite golf hole in his life played downhill, gradually or severely, and normally was downwind as well.

Dan Jenkins

I was lucky to start working when German cinema was having an interesting moment. Now the quality is going downhill again because they're insisting on doing comedies. We should know by now that we make good cars but we're not the funniest people.

Daniel Bruhl

Alzheimer's is a disease for which there is no effective treatment whatsoever. To be clear, there is no pharmaceutical agent, no magic pill that a doctor can prescribe that will have any significant effect on the progressive downhill course of this disease.

David Perlmutter

My best year was probably 1948, and after that, it's been downhill for me.

Dennis Farina

For better or worse, zoos are how most people come to know big or exotic animals. Few will ever see wild penguins sledding downhill to sea on their bellies, giant pandas holding bamboo lollipops in China or tree porcupines in the Canadian Rockies, balled up like giant pine cones.

Diane Ackerman

Television's going, as far as I'm concerned, downhill, and I'm an anachronism.

Dick Van Dyke

All the best companies quickly go downhill after the departure of people like Bill Gates - even when such very able people have tried very very hard to avoid exactly this problem.

Dominic Cummings

Going to the Combine, I had a lot of eyes on me, high praise on me, so I had to perform well at the Combine, or everything would have just went downhill.

Donte DiVincenzo

Dad met Mom in 1983 during the lead-up to the 1984 games. She was an Olympic downhill skier. In those days, the winter and summer games were held in different cities but in the same year, so there was more intermingling of winter and summer athletes at social functions.

Douglas Brunt

Hearts was the pinnacle of my career. After I left, it really was downhill. Hearts is the club I always associate myself with, and I'm proud to have played for them.

Drew Busby

Trauma survivors have a deficiency in their capacity to regulate emotions - they're too prolonged and too intense and too negative. As a corollary to affect regulation, self-esteem, sense of self and inter-personal functioning all goes downhill. And that's a chronic thing that's solved in an-inter personal context.

Drew Pinsky

I think the moment you start trying to please a fan base is when you start going downhill. I'm going to always, always write about what I want, even if it doesn't necessarily cater to most of them.

Ed Sheeran