The development of methods to monitor protein dynamics in cells together with the discovery of specific and general lysosomal inhibitors have resulted in the identification of different classes of cellular proteins, long- and short-lived, and the findings of the differential effects of the inhibitors on these groups.
Aaron Ciechanover
We don't swim for the attention. We don't swim to be rock stars. There is something beautiful about being in an anonymous sport and being fairly anonymous. It enables you do something you love without any of the other effects.
Aaron Peirsol
The crippling health and economic effects of the COVID-19 crisis have been felt across Central Virginia. But in our communities of color, COVID-19's spread has been particularly destructive.
Abigail Spanberger
I personally don't like to use as many effects because when you play live, something always goes wrong.
Adam Jones
If you make action movies, the critics will savage you, and then your movies are outdated the following week with the new wave of special effects.
Adam McKay
Drugs ruin peoples lives, break up families and have disastrous effects on our communities.
Adam Rickitt
Until the 1990s, there were few reliable observations about movement at the scale of the entire universe, which is the only scale dark energy effects. So dark energy could not be seen until we could measure things very, very far away.
Adam Riess
Whether it's the experiments on 'MythBusters' or my earlier work in special effects for movies, I've regularly had to do things that were never done before, from designing complex motion-control rigs to figuring out how to animate chocolate.
Adam Savage
After a prosperous, but to me very wearisome, voyage, we came at last into port. Immediately on landing I got together my few effects; and, squeezing myself through the crowd, went into the nearest and humblest inn which first met my gaze.
Adelbert von Chamisso
When I work, I'm thinking in terms of purely visual effects and relations, and any verbal equivalent is something that comes afterwards. But it's inconceivable to me that I could experience things and not have them enter into my painting.
Adolph Gottlieb
The very first pharmaceutical commercial I ever heard was 15 seconds of the product and 45 seconds of side effects, so I know that this cannot be good for you.
Al Jourgensen
Besides the mistakes that are pointed out, I love the way readers become involved with the characters. When readers start asking about character motivations instead of concentrating on the special effects, it means you're connecting with them on a personal level.
Alan Dean Foster
Any effects created before 1975 were done with either tape or echo chambers or some kind of acoustic treatment. No magic black boxes!
Alan Parsons
There are psychological repercussions to illness and we need a little more help to get through the effects not only on the afflicted but on the family. And I think there's even a place for humor in that.
Alan Thicke
Learning would be exceedingly laborious, not to mention hazardous, if people had to rely solely on the effects of their own actions to inform them what to do.
Albert Bandura
Mr. Speaker, I am deeply concerned that many regions of this world are suffering from the effects of armed conflicts with religious aspects. I believe that the differences of faith are not the real reason for these conflicts.
Alcee Hastings
It's harder to make real audio than special effects audio.
Alejandro Gonzalez Inarritu
The Food and Drug Administration works to protect the interests of all patients and provide them with reliable information about the potential effects of treatments. But government rules should not stand in the way of potentially lifesaving therapies for those who do not have much time or any other options.
Alex Azar
Even as global warming increases the frequency of El Nino and the Atlantic event, their effects are being amplified by the annual loss of an area of rain forest the size of New Jersey. Less rain falls, and the water runs into the rivers instead of being sucked up by the fungus filaments and tree roots.
Alex Shoumatoff
There's always a momentum in how users do stuff. Making small changes can have huge knock-on effects for whole companies.
Alex Stamos
One of the most unfortunate side effects of the urban activism of the '60s and '70s is the belief that development is wrong and that fighting it makes you an environmentalist.
So many times I've heard people say that the right to marry for gay and lesbian couples won't really change anything other than some legal and financial stuff. It's a dumb argument: those legal and financial effects matter.
Our technological powers increase, but the side effects and potential hazards also escalate.
I'm not first and foremost interested in story and the what-happens, but I'm interested in who's telling it and how they're telling it and the effects of whatever happened on the characters and the people.
Everyone has the ability to increase resilience to stress. It requires hard work and dedication, but over time, you can equip yourself to handle whatever life throws your way without adverse effects to your health. Training your brain to manage stress won't just affect the quality of your life, but perhaps even the length of it.
Being ill-prepared and unequipped to deal with life's inevitable challenges leaves us vulnerable to the dangerous effects of stress.
In an economy increasingly dominated by network effects, peer-to-peer transactions, self-regulation, and contract labor, the old frameworks are woefully irrelevant.
In speaking, for convenience, of devices and expedients, I did not intend to imply that Shakespeare always deliberately aimed at the effects which he produced.
If Canada could simply apply the basic principles of sustainable development, such as the internalization of costs and 'polluters pay,' it would have long-term beneficial effects, both environmental and economic.
We are working to understand and regulate per- and polyfluoroalkyl synthetic chemicals, known as PFAS and PFOS, used to make water-repellent fabrics and non-stick products. These chemicals have been in prevalent use since the 1940s, but we need to learn more about their potential effects on human health and the environment.
Limit or eliminate late-night computer and television viewing. A computer or TV screen may seem much dimmer than a light bulb, but these screens often fill your field of vision, mimicking the effects of a room filled with light.
I'm still not comfortable recommending that people eat saturated fat with abandon, but it's clear to me that sugar, flour and oxidized seed oils create inflammatory effects in the body that almost certainly bear most of the responsibility for elevating heart disease risk.
What you can do with visual effects is enhance the look of the character, but the actual integrity of the emotional performance and the way the character's facial expressions work, that is what is going to be created on the day with other actors and the director.
When I'm working on the scripts or working with the other actors or rehearsing with the director, and when the director is cutting the movie, and we've shot the scene, the director is not looking at the visual effects.
Summer blockbusters are very expensive to make. They have things that have to be expensive, such as 600 effects shots or CG characters that have to go a certain way, or a film design that is different but expensive.
I was born in Edinburgh, in Scotland, a few days after the end of the Second World War. Both my parents had left school at a very young age, unwillingly in my father's case. Yet both had deep effects on my education, my father influencing me toward measurement and mathematics, and my mother toward writing and history.
Do some research on the effects of television and your brain, and I promise you you'll have a decision to make when it comes to television, especially with what you watch.
I've been working in radio on and off for most of my career. There's a restfulness about it. It's more focused on the voice, so you don't have to worry about extraneous things like sound effects, as there's someone there to look after that.
At Girl Scouts, we are committed to raising awareness about the terrible effects of cyber bullying, and to teaching girls how to recognize the signs of bullying of any sort and extricate themselves or another from a bad situation before it spirals out of control and ends in tragedy.
In space, everything is dependent on everything else and one hiccup causes a lot of ripple effects.
We have finally started to notice that there is real curative value in local herbs and remedies. In fact, we are also becoming aware that there are little or no side effects to most natural remedies, and that they are often more effective than Western medicine.
Tame Impala's music revisits a time when guitar effects and studio tricks were music's newest frontiers; when rock was barely old enough to drive and violently threw conventional ideas out the window.
Tightly embracing guitar effects and tape loops, Mission of Burma made sound an important commodity in rock 'n' roll, and its members carried that tradition into their first album after a 19-year hiatus, 2004's 'ONoffON.'
How little do we discover in comparison of those things which now are and forever will be hidden from our sight? The whole of which I am fully persuaded no one will ever be able to dive into, and to explain their causes and effects.
Laughter is a tranquilizer with no side effects.
For strange effects and extraordinary combinations we must go to life itself, which is always far more daring than any effort of the imagination.
Civilization, we shall find, like Universalism and Christianity, is anti evolutionary in its effects; it works against the laws and conditions which regulated the earlier stages of man's ascent.
The Laffer Curve illustrates the basic idea that changes in tax rates have two effects on tax revenues: the arithmetic effect and the economic effect.
The income effects in an economy always sum to zero.
Trade allegedly does not foster growth because when it begins, a flood of imports of factory origin destroys the handicraft manufacturing of the less developed country: the models for this are the effects of British exports of textiles and of iron in India and Chile in the first half of the nineteenth century.
