The problem of different sensitivities of distinct protein groups to lysosomal inhibitors has remained unsolved and may have served as an important trigger in the future quest for a non-lysosomal proteolytic system that may be involved in at least certain aspects of intracellular protein degradation.
Aaron Ciechanover
I'm not a politician, but ISIS is a problem, and this matter should be solved very quickly. This will affect existing production, it will affect investment, it will affect the behaviour of people. It will affect the area tremendously.
Abdallah Salem el-Badri
Good intentions and grand theories do not make a good programme. Programmes work best when they're based on a detailed understanding of the problem being solved and how they are implemented on the ground.
Abhijit Banerjee
I do not expect the Union to be dissolved - I do not expect the house to fall - but I do expect it will cease to be divided. It will become all one thing, or all the other.
Abraham Lincoln
Problems should be solved by talking and not in an aggressive manner.
Ada Yonath
For much of Toyota's history, we have ensured the quality and reliability of our vehicles by placing a device called an andon cord on every production line - and empowering any team member to halt production if there's an assembly problem. Only when the problem is resolved does the line begin to move again.
Akio Toyoda
On television and in the movies, crimes are always solved. Nothing is left uncertain. By the end, the viewer knows whodunit. In real life, on the other hand, many murders remain unsolved, and even some that are 'solved' to the satisfaction of the police and prosecutors lack sufficient evidence to result in a conviction.
Alan Dershowitz
For me, consciousness is the most interesting unsolved problem of science, and, in fact, we may never know what it is about a particular arrangement of neurons that gives rise to consciousness. Our consciousness, like the air we breathe or like the passage of time, is central to our existence as intelligent beings.
Alan Lightman
No problem can be solved from the same level of consciousness that created it.
Albert Einstein
But if our hopes are betrayed, if we are forced to resist the invasion of our soil, and to defend our threatened homes, this duty, however hard it may be, will find us armed and resolved upon the greatest sacrifices.
Albert II of Belgium
The Middle East is literally going up in flames, as is California, and Katrina's problems haven't been solved, and Congress' response is to criticize Federal judges.
Alcee Hastings
We have far more options for black Americans to tell stories outside of slavery, but whenever it comes to slavery, it's an uncomfortable subject. Why? Because it's the most unresolved subject in American history.
Aldis Hodge
A vigorous and profitable drug industry is not a problem to be solved but a goal to be encouraged.
Alex Azar
I could obtain any paper by pirating it, so I solved many requests and people always were very grateful for my help. After that, I created sci-hub.org website that simply makes this process automatic and the website immediately became popular.
Alexandra Elbakyan
The results of any traumatic experience, such as abuse, can only be resolved by experiencing, articulating, and judging every facet of the original experience within a process of careful therapeutic disclosure.
Alice Miller
As someone who has seen war first hand, and as a father of three young adults, it was my hope that we could have resolved this conflict and disarmed Saddam Hussein without war. However, this was not the case.
Allen Boyd
Serious poetry deals with the fundamental conflicts that cannot be logically resolved: we can state the conflicts rationally, but reason does not relieve us of them.
Allen Tate
With such thoughts in your mind, now that you have resolved to love Him and please Him with all your strength, your only fear should be to fear God too much and to place too little confidence in Him.
Alphonsus Liguori
Does the entry of Indian H-1B worker augur a change in the relations of production in the world of cybertechnology? No, but the presence of such workers - their skills and their histories - introduce contradictions into the system that are not always easily absorbed or dissolved.
Amitava Kumar
Divorce is horrible. I wouldn't wish that on my worst enemy. I don't think it's anything that's ever completely resolved.
Andie MacDowell
I resolved to stop accumulating and begin the infinitely more serious and difficult task of wise distribution.
I read 'Treasure Island' for the first time at university. And I started to notice then how unresolved some things were. Later, I realised that Stevenson was interested in sequels, and I wondered whether he would have gone back to it had he lived longer.
A lot of problems get solved in those sort of in-between moments when your subconscious has been working on some problem. If you keep it spinning, you can fix ideas sometimes better than if you focus on them directly.
Pure mathematicians just love to try unsolved problems - they love a challenge.
If you go deep into a problem, you'll find most all of the time that there are yet more problems to be solved from the ground up.
There's no problem on the planet that can't be solved without violence. That's the lesson of the civil rights movement.
Everything I do in my life is very instinctual and in the moment. If I'm attracted to something, that's it. If I have reservations, those don't change till they're resolved. My first impression is how I go.
On the one hand, the financial projection is on the agenda - we will see if this problem can be resolved or not. I think it is a right idea to stage a special summit, which would deal with the question of priorities of European politics.
Even people who aren't pleasant to deal with - it's often because they're unhappy, and something's still not resolved for them.
You can't raise the aspirations of a child and then leave them hanging. Poverty can't be solved by a project. It's solved by a relationship, collaboration.
The conflict in the Middle East needs to be solved for the same reasons. It is necessary to reach a two-states solution, built on international law, for sustainable peace and development, and it can only be achieved through joint efforts by the international community.
With the club now in administration and concern about where the money for land sale has gone, I know there are huge commercial difficulties to be resolved, but I hope that football will once again become the most important issue.
When I watch my kids, and I see the primal level at which the sibling relationships are formed, then I completely understand what these unresolved adult sibling problems are based on. You know, 'Mom liked you better' and, 'You got your own room and I didn't.'
People relate to things that feel real to them. All the good, happy, over-sexed and moneyed endings on TV are not the way most of us feel in our lives. The success of 'E.R.,' I think, is not relying on overly sentimental stories that are solved where people's lives wrap up nicely with happy endings.
To allow the policy question of same-sex marriage to be considered and resolved by a select, patrician, highly unrepresentative panel of nine is to violate a principle even more fundamental than no taxation without representation: no social transformation without representation.
Nowhere in the world has the use of force alone resolved a conflict.
I'd fallen in love with a woman but she broke up with me and I was devastated. Six months later, I went into a suicidal depression from the break-up of the relationship, but I resolved to not do what my friends had done. And so I reached out for help.
The world has a huge number of trillion-dollar problems wanting to be solved, and biology is the only way to do that.
In 2001, we didn't have an army; we had remnants of a dissolved army that had no hope. Our generals had literally become busboys.
I don't start with the characters. I start with the series of events that will provide the conflict and how it can be resolved. Characters are incidental.
Delhi government doesn't have the power to open new colleges. Once Delhi gets full statehood, this is a very big issue that will be solved.
If there are differences of views or divergence of ideas, they can be resolved through discussion and dialogue.
If I'm going for a shot, then I've just resolved to go for it and not think too much about it.
Never let a problem to be solved become more important than a person to be loved.
Poor decision making in government; the tragedy of short-term economic thinking; our national housing crisis: these are real 21st Century problems for our country. They are problems that can only be solved by genuinely fearless thinking about our natural environment.
It's unresolved conflict in my life that I have a lovely family and a risky job.
I realize that much will be asked of me, yet I am resolved to accept it as a great and splendid task.
Marx, as we have seen, solved it by declaring capital to be a different thing from product, and maintaining that it belonged to society and should be seized by society and employed for the benefit of all alike.
Human spirit is the ability to face the uncertainty of the future with curiosity and optimism. It is the belief that problems can be solved, differences resolved. It is a type of confidence. And it is fragile. It can be blackened by fear and superstition.
What I really like about law is that it's not an endless discourse like history or philosophy. In law, there comes a point where problems have to be solved, and cases decided.
