Everybody else is afraid to fail. I do not really care because when I fail, I try something new.

The combination of brilliant ideas and entrepreneurial spirit should lead us to a safer and more secure future.

If I collected all the diamonds in the world, I'd have no 'income' but I'd have a lot of 'assets'. Would my company be worth nothing because I have no income? A lot of Net companies are collecting assets. They have to be measured with a new set of metrics.

If everyone played it safe, we wouldn't get anywhere.

Entrepreneurs have the flexibility and the ability to do things that large companies simply cannot. Could a large company pull off a trick like Amyris, going from anti-malaria medicine to next-generation fuel?

Will biofuel usage require land? Absolutely, but we think the ability to use winter cover crops, degraded land, as well as using sources such as organic waste, sewage, and forest waste means that actual land usage will be limited. Just these sources can replace most of our imported oil by 2030 without touching new land.

Knowing whose advice to take and on what topic is the single most important decision an entrepreneur can make.

When I started doing things on my own, I was figuring - remember, it was a very nascent market. And there was a lot that was unknown about the renewable marketplace in 2004, early 2003, when I was planning on it.

Eighty percent of what doctors do, tech can do at a fraction of the cost - especially your rural doctor in India.

Seeking an acquisition from the start is more than just bad advice for an entrepreneur. For the entrepreneur it leads to short term tactical decisions rather than company-building decisions and in my view often reduces the probability of success.

I've probably failed more often than anybody else in Silicon Valley. Those don't matter. I don't remember the failures. You remember the big successes.

I generally disagree with most of the very high margin opportunities. Why? Because it's a business strategy tradeoff: the lower the margin you take, the faster you grow.

The winter period between September and March in this country, when land sits fallow and is subject to topsoil loss, we could be enriching the soil and growing all the biomass we need to replace imported gasoline.

We like to say at Khosla Ventures, and this is one of the reasons to do what we do, we'll take technical risks that nobody else will.

If you have a carbon cap and trade system, there'd be an agreed-to limit the amount of carbon we emit. That changes the economic picture for fossil technologies and for the renewable technologies. It makes the renewable technologies more attractive and the fossils less attractive.

Now it will take a long time to scale biofuels, but I'm the only one in the world forecasting oil dropping in price to $35 a barrel by 2030. I'll put it on the record: Oil will not be able to compete with cellulosic biofuels. If you do it from food, the food will get so expensive you can't make fuel out of it.

I'm not a political person. I'm a techie nerd, and I enjoy the techie part. I mean, all my life, I've loved great technology.

The U.S. has fallen well behind Europe in recognizing climate change and the implications of climate change.

There are parts of the country in America, in the Midwest, where wind is a big resource, and we should absolutely use it. But to try and apply it nationally doesn't make sense. There are technologies that will work that are appropriate to certain regions.

Is it 10 years, 20, 50 before we reach that tipping point where climate change becomes irreversible? Nobody can know. There's clearly a probability distribution. We need to ensure this planet, and we need to do it quickly.

I do not know what got me interested in technology. What was very clear to me very early on was that I was not interested in religion and that naturally increased my curiosity about science and technology, and I fundamentally believe the two are conflicting.

What an entrepreneur does is to build for the long run. If the market is great, you get all of the resources you can. You build to it. But a good entrepreneur is always prepared to throttle back, put on the brakes, and if the world changes, adapt to the world.

In my view, it's irreverence, foolish confidence and naivety combined with persistence, open mindedness and a continual ability to learn that created Facebook, Google, Yahoo, eBay, Microsoft, Apple, Juniper, AOL, Sun Microsystems and others.

Imagine the world of mobile based on Nokia and Motorola if Apple had not been restarted by a missionary entrepreneur named Steve Jobs who cared more for his vision than being tactical and financial.

First, you should take money and have plenty of money fueling your tank. But money becomes dangerous if you assume it's going to keep coming. Make sure you can get your burn rate to a sustainable level if you hit the brakes hard, within 90 days.

We love serious technology innovations, and there is a strong bias towards large technology innovations that are sort of disruptive to the current market.

You take something like RingCentral. It doesn't need any more money or financing: it is relatively mature, recurring revenue business - not really worried - but you know, we could sell it tomorrow. We have not been in a rush to sell it. We don't care about exits as much. We care about building fundamental value.

Our focus is not on exit. In fact if you talk to any of my entrepreneurs, I'm generally saying, 'Don't sell the company,' when other investors want to sell. I'd much rather focus on building long-term value in building companies rather than worrying about exits.

My life is full of way more mistakes than successes.

Germany has a lot of solar power. In fact, in 2005, some 55 or 57 percent of worldwide installations were photovoltaics in Germany. That's 57 percent of all worldwide solar photovoltaics. Because of the high feed-in tariff, they have a way of allowing you to produce electricity and ship it into the grid at very high prices.

There's a big difference between needs and requirements for grid-based electricity versus those for distributed rural homes or remote locations, or even rooftop solar, where photovoltaics do OK. The more economical a technology is, the faster we'll see adoption.