Run for office? No. I've slept with too many women, I've done too many drugs, and I've been to too many parties.

I had to stop going to auditions thinking, 'Oh, I hope they like me.' I had to go in thinking I was the answer to their problem.

My biggest fear is doing the same things 10 years from now. That would be a failure. It's something you have to constantly reassess, and asking yourself what you are going to do next makes it a good, long full journey.

There's a funny thing about fame. The truth is you run as fast as you can towards it because it's everything you want. Not just the fame but what it represents, meaning work, meaning opportunity. And then you get there, and it's shocking how immediately you become enveloped in this world that is incredibly restricting.

The idea that every time you do a film you're supposed to be tortured confuses me. I mean, guys who say, 'Oh, it's really tough, my character is really suffering' -come on. For us, even in the rotten ones we've had a good time. I don't think you have to suffer.

I'm so lucky to have been raised the way I have, because my parents believed that everyone had the right to their own feelings, opinions, and existence; as long as they weren't harming others, you had to defend those rights.

I'm really white trash.

After doing One Fine Day and playing a pediatrician on ER, I'll never have kids. I'm going to have a vasectomy.

When you're young you believe it when people tell you how good you are. And that's the danger, you inhale. Everyone will tell you you're a genius, which you are not, and if you understand that, you win.

It's incredibly unfair. You don't see a lot of 60-year-old women with 20-year-old men onscreen.

In the '60s, when I was growing up, one of the great elements of American culture was the protest song. There were songs about the civil rights movement, the women's rights movement, the antiwar movement. It wasn't just Bob Dylan, it was everybody at the time.

In doing the screenplay for 'Good Night, and Good Luck,' the most important thing for me was to constantly go back to wherever the opposition would argue. So I had to keep reading all the books and articles about why McCarthy is such a good guy.

I've been my most happy and my most unhappy in relationships. I have family and friends and people I care very much about. I've got a really, really, really good life.

One of my favorite films is 'Big Fish,' which I think is a masterpiece.

Directing is really exciting. In the end, it's more fun to be the painter than the paint.

Hosting is work. It means you don't get to go up to your room and disappear and take a nap. Like everybody else does after lunch. I'm talking about hosting, not hosting a dinner party, but hosting people staying in your home.

I'm kind of comfortable with getting older because it's better than the other option, which is being dead. So I'll take getting older.

If you're famous, I don't - for the life of me - I don't understand why any famous person would ever be on Twitter.

The first thing that I learned - and I understood it at a really young age - was that I could get a laugh. Really early. Because my mother and father are funny.

I certainly direct with confidence even if I'm not confident. I learned early on as an actor that confidence can be faked, and it's not always a terrible thing to do. A lot of times if people feel you're confident, then they're confident.

I don't know if winning at any cost is wrong or not. There are times I've thought that the end justified the means.

Directors are the captains of the ship, and it's your job as the lead actor to make sure that the rest of the cast understand that by doing whatever he says.

I'm the least metrosexual cat you've ever met. I've never had my fingernails or toenails done, and I've cut my own hair longer than other people have cut my hair.

I was in a bar and I said to a friend, 'You know, we've become those 40-year-old guys we used to look at and say, 'Isn't it sad?'

On Christmas morning, before we could open our Christmas presents, we would go to this stranger's home and bring them presents. I remember helping clean the house up and putting up a tree. My father believed that you have a responsibility to look after everyone else.

The people I've respected most in the industry over the years - Paul Newman, for instance. I just loved the way he handled growing old on-screen. It's understanding that you're now basically a character actor. Which is fine, but you have to pay attention to it.

I've certainly done some turkeys along the way and made some dumb choices in my career, mostly early on. I'm one of the lucky ones who got to make a lot of mistakes very early when no one was paying attention.

I think anyone who is famous is a moron if they're on Twitter. It's just stupid.

I've been working with Pat Robertson on Africa debt-relief, and we disagree on virtually everything except certain very specific, inalienable rights, and the truth is that morality and patriotism come in all shapes and sizes.

I do know something about the news world. I was sitting on the floors of newsrooms since I was seven years old, and I've been around them my whole life. I understand that someone looks at a story with famous people in it, and you want to put it out.

I'm not out trying to prove anything. I'm sort of finished with that, so I get to play in other sandboxes and try and figure out what I like and I'm interested in.